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Journal of Experimental Medicine文章:miR-612抑制肝癌的入侵及转移

日期:2019/05/19  来源:新葡萄京娱乐场官方网站

  

  在与癌症相关的死亡中,超过90%是由于肿瘤转移导致的。肿瘤转移长久以来都是癌症预后及治疗的瓶颈。肿瘤入侵-转移的信号级联网络十分复杂且步骤繁多,miRNA在其中发挥着十分重要的作用。在本研究中,编辑使用miRNA芯片检测了初期肝癌和肺转移肝癌样本中miRNA表达水平的差异。CapitalBio Mammalian miRNA microarray检测服务,在北京新葡萄京娱乐场官方网站生物技术有限企业完成。研究结果显示有32种miRNA与肝癌的转移有关,在这些miRNA中,miR-612首次被发现与肝癌细胞的增殖,迁移,入侵和转移相关。此外,研究证实miR-612可通过其中一个靶向基因AKT2来抑制上皮-间叶转化(EMT)和癌细胞的转移。在肝癌患者中,miR-612的水平与肿瘤的大小,阶段,EMT和癌细胞转移成反比。特别重要的是,在癌细胞转移信号级联网络中,miR-612抑制病灶部位癌细胞的入侵和远距离的癌细胞移殖,不仅参与其中的起始步骤,也参与最终的步骤。本研究有助于大家进一步了解肝癌这种高度恶性肿瘤的发病机制,同时miR-612在肝癌转移级联信号网络中扮演的这一多功能角色为其作为早期和晚期肝癌的有效靶点提供了理论支撑。本研究于2013年3月在线发表在Journal of Experimental Medicine(影响因子:14.776)。


原文摘要:

  miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma

  MicroRNAs (miRNAs) play a critical role in tumor metastasis. In this study, we identified a set of 32 miRNAs involved in hepatocellular carcinoma (HCC) metastasis. Among them, miR-612 was shown for the first time to have inhibitory effects on HCC proliferation, migration, invasion, and metastasis. AKT2 was verified to be one of the direct targets of miR-612, through which the epithelial–mesenchymal transition (EMT) and metastasis were inhibited. The level of miR-612 in HCC patients was inversely associated with tumor size, stage, EMT, and metastasis. Of particular importance, miR-612 is involved in both the initial and final steps of the metastatic cascade, by suppressing local invasion and distant colonization. The pleiotropic roles of miR-612 in the HCC metastatic cascade suggest that it could be an effective target for both early and advanced HCC.

 

原文出处:http://jem.rupress.org/content/early/2013/03/05/jem.20120153.abstract

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